发表论文

36. Qiao, Y.^#; Zhao, B.Y.^#; Cheng, R.S.; Peng, Y. e.*; Ma, X.X.*; Zhang, S. Twelve-Hour Dynamic Monitoring of Microalgae Response to Oxidative Stress by Single-Cell Metabolomics Analysis. Anal. Chem. 2026, in press

35. Qian, Y.; Yu, Q.; Ni, Z.X.; Ouyang, Z.; Ma, X.X.^*; Resolving Spectral Complexity in 4D Lipidomics Using a Two-Dimensional Deconvolution Framework. Angew. Chem. Int. Ed. 2026, 65, 6117030.

34.  Li, D.; Qian, Y.; Tan, A.L.; Ye, S.H.; Xie, Z.N.; Ouyang, Z.; Ma, X.X.^*; Tissue Heterogeneity-Driven Parallel Acquisition for High-Coverage MS/MS Imaging of Lipids. Angew. Chem. Int. Ed. 2026, 65 (31). 4721868.

33. Yu, Q.R.; Ma, X.X.*; Chemical reaction-enabled lipidomics: from sensitive structural analysis to biomedical applications. Analyst 2026, 151 (6), 1538–1548. 

32. Cheng, S.M.; Wu, D.N.; Gong, X.Y.*; Ma, X.X.*; Enabling Live Single-Cell Metabolomics: Mass Spectrometry Technologies and Functional Applications. Health Metab. 2026, 3 (1), 4. 

31. Xie, Z.N.; Yu, Q.R.; Cheng, S.M.; Li, D.; Ouyang, Z.; Ma, X.X.*; ¹³C-Isotope Tracing Structural Lipidomics for Resolving Phospholipid Metabolism Dynamics in Human Breast Cancer Cells. Anal. Chem. 2026, 98 (3), 2401–2413. 

30. Xie, Z.N.; Cheng, S.M.; Gong, X.Y.; Ma, X.X.*; Applications of Stable Isotopes in Lipid Metabolic Tracing and Lipidomics Analysis. TrAC, Trends Anal. Chem. 2026, 196, 118629. 

29. Cai, Z.J.; Li, N.X.; Cheng, S.M.; Ouyang, Z.*; Ma, X.X.*; Single-cell structural lipidomics using a miniature dual-LIT mass spectrometer. Chem. Sci. 2026, 17 (7), 3828–3840. 

28. Liu, M.R.; Ma, H.Z.; Fang, X.; Chen, Y.H.; Wang, Z.Y.*; Ma, X.X.; Norm-SVR for the Enhancement of Single-Cell Metabolomic Stability in ToF-SIMS. Metabolites 2025, 16 (1), 36. 

27. Zhang, F.J.; Cao, C.X.; Zhuang, J.L.; Liu, P.; Ma, X.X.; High-throughput single-cell lipidomics reveals stage-specific phospholipid remodeling and ferroptosis-related signatures in the Evolution of plasma cell dyscrasia. Blood 2025, 146 (Suppl. 1), 7458. 

26. Zhu, J.W.; Yang, Y.Q.; Cao, C.X.; Tian, J.L.; Chai, H.C.; Ma, X.X.; Wang, W.H.* DLD-based on-chip sample handling for label-free single-cell MS cytometry. Anal. Methods 2025, 17 (43), 8810–8817. 

25. Qian, Y.; Ma, X.X.*; Advances in Tandem Mass Spectrometry Imaging for next-generation spatial metabolomics. Anal. Chem. 2025, 97 (14), 7589–7599. 

24. Tan, A.L.; Ma, X.X.*; Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics. Chin. Chem. Lett. 2024, 35 (8), 109276. 

23. Cheng, S.M.^#; Cao, C.X.^#; Qian, Y.; Yao, H.; Gong, X.Y.; Dai, X.H.*; Ouyang, Z.*; Ma, X.X.*; High-throughput single-cell mass spectrometry enables metabolic network analysis by resolving phospholipid C═C isomers. Chem. Sci. 2024, 15 (17), 6314–6320. 

22. Guo, X.Y.; Cao, W.B.; Fan, X.M.; Chen, Q.H.; Wu, L.; Ma, X.X.; Ouyang, Z.; Zhang, W.P.* MS³ imaging enables the simultaneous analysis of phospholipid C═C and sn-position isomers in tissues. Anal. Chem. 2024, 96 (10), 4259–4265. 

21. Qian, Y.; Guo, X.Y.; Wang, Y.F.; Ouyang, Z.*; Ma, X.X.*; Mobility-Modulated Sequential Dissociation Analysis Enables Structural Lipidomics in Mass Spectrometry Imaging. Angew. Chem. Int. Ed., 2023, 62 (52), e202312275. 

20. Li, N.X.; Cai, Z.J.; Zhang, Z.Y.; Zhang, W.P.; Ma, X.X.; Zhou, X.Y.; Ouyang, Z.*; Temperature-tuning desorption ionization for ambient mass spectrometry. Anal. Chem., 2023, 95 (29), 11099–11105. 

19. Li, D.; Qian, Y.; Yao, H.M.; Yu, W.Y.; Ma, X.X.*; DeepS: Accelerating 3D mass spectrometry imaging via a deep neural network. Anal. Chem., 2023, 95 (29), 10879–10886. 

18. Zhao, P.; Feng, Y.X.; Wu, J.H.; Zhu, J.W.; Yang, J.L.; Ma, X.X.; Ouyang, Z.; Zhang, X.R.; Zhang, W.P.; Wang, W.H.* Efficient sample preparation system for multi-omics analysis via single cell mass spectrometry. Anal. Chem., 2023, 95 (18), 7212–7219. 

17. Li, D.; Ouyang, Z.; Ma, X.X.*; Mass spectrometry imaging for single-cell or subcellular lipidomics: a review of recent advancements and future development. Molecules, 2023, 28 (6), 2712. 

16. Cheng, S.M.; Zhang, D.H.; Feng, J.X.; Hu, Q.Y.; Tan, A.L.; Xie, Z.N.; Chen, Q.H.; Huang, H.M.; Wei, Y.; Ouyang, Z.*; Ma, X.X.*; Metabolic pathway of monounsaturated lipids revealed by in-depth structural lipidomics by mass spectrometry. Research, 2023, 6, 0087. 

15. Cheng, S.M.; Xie, Z.N.; Hu, Q.Y.; Qian, Y.; Ma, X.X.*; Familiarizing undergraduate students with advanced Mass Spectrometry techniques: an example of detailed lipid structure characterization. J. Chem. Educ., 2023, 100 (3), 1270–1276. 

14. Guo, X.Y.; Cao, W.B.; Fan, X.M.; Guo, Z.; Zhang, D.; Zhang, H.; Ma, X.X.; Dong, J.; Wang, Y.*; Zhang, W.P.*; Ouyang, Z.*; Tandem mass spectrometry imaging enables high definition for mapping lipids in tissues. Angew. Chem. Int. Ed. 2023, 62 (9), e202214804. 

13. Liu, X.W.; Jiao, B.; Cao, W.B.; Ma, X.X; Xia, Y.; Blanksby, S.J.; Zhang, W.P.; Ouyang, Z.*; Development of a miniature mass spectrometry system for point-of-care analysis of lipid isomers based on ozone-induced dissociation. Anal. Chem., 2022, *94* (40), 13944–13950. 

12. Zhao, P.; Cheng, S.M.; Feng, Y.X.; Liang, F.; Zhang, X.R.; Ma, X.X; Wang, W.H.*; Automated and miniaturized pico-liter metabolite extraction system for single-cell mass spectrometry. IEEE Trans. Biomed. Eng., 2022, 70 (2), 470–478. 

11. Zhao, X.; Zhang, S.C.; Ma, Q.; Zhang, X.R.; Ma, X.X.*; Rapid Disulfide Mapping in Peptides and Proteins by meta-Chloroperoxybenzoic Acid (m-CPBA) Oxidation and Tandem Mass Spectrometry. Anal. Chem. 2021, 93 (44), 14618–14625. 

10. Ma, X.X.; Zhang, W.P.; Li, Z.S.; Xia, Y.; Ouyang, Z.*; Enabling high structural specificity to lipidomics by coupling photochemical derivatization with tandem mass spectrometry. Acc. Chem. Res. 2021, 54 (20), 3873–3882. 

9. Li, Z.S.; Cheng, S.M.; Lin, Q.H.; Cao, W.B.; Yang, J.; Zhang, M.M.; Shen, A.J.; Zhang, W.P.; Xia, Y.; Ma, X.X*; Ouyang, Z.*; Single-cell lipidomics with high structural specificity by mass spectrometry. Nat. Commun. 2021, 12 (1), 2869. 

8. Feng, J.X.; Zhao, H.S.; Gong, X.Y.; Xia, M.C.; Cai, L.S.; Yao, H.; Zhao, X.; Yan, Z.H.; Li, Z.P.*; Nie, H.G.; Ma, X.X*; Zhang, S.C.*; In situ identification and spatial mapping of microplastic standards in paramecia by secondary-ion mass spectrometry imaging. Anal. Chem. 2021, 93 (13), 5521–5528. 

7. Zhang, J.; Huo, X.M.; Guo, C.G.; Ma, X.X; Huang, H.X.; He, J.M.; Wang, X.; Tang, F.*; Rapid imaging of unsaturated lipids at an isomeric level achieved by controllable oxidation. Anal. Chem.2021, 93 (4), 2114–2124. 

6. Zhu, X.W.; He, Q.; Xu, F.J.; Ma, X.X.; Xing, Z.; Zhang, S.C.; Zhang, X.R.* The screening of intermediates in a ruthenium and iridium ion-catalyzed gas-phase reaction of ethanol converting to butanol by ICP-MS/MS. J. Anal. At. Spectrom.;2020, 35 (4), 804–809. 

5. Zhao, J.; Xie, X.B.; Lin, Q.H.; Ma, X.X; Su, P.; Xia, Y.* Next-generation Paternò–Büchi reagents for lipid analysis by mass spectrometry. Anal. Chem. 2020, 92 (19), 13470–13477.

4. Li, Z.S.; Wang, Z.Y.; Pan, J.; Ma, X.X; Zhang, W.P.; Ouyang, Z.* Single-cell mass spectrometry analysis of metabolites facilitated by cell electro-migration and electroporation. Anal. Chem. 2020, 92 (14), 10138–10144.

3. Li, H.F.; Cao, W.B.; Ma, X.X; Xie, X.B.; Xia, Y.; Ouyang, Z.* Visible-light-driven [2+2] photocycloadditions between benzophenone and C═C bonds in unsaturated lipids. J. Am. Chem. Soc. 2020, 142 (7), 3499–3505.

2. Guo, X.Y.; Bai, H.; Ma, X.X; Li, J.; Ren, Y.; Ouyang, Z.; Ma, Q.* Online coupling of an electrochemically fabricated solid-phase microextraction probe and a miniature mass spectrometer for enrichment and analysis of chemical contaminants in infant drinks. Anal. Chim. Acta 2020, 1098, 66–74.

1. Cao, W.B.; Cheng, S.M.; Yang, J.; Feng, J.X.; Zhang, W.P.; Li, Z.S.; Chen, Q.H.; Xia, Y.; Ouyang, Z.*; Ma, X.X*; Large-scale lipid analysis with C═C location and sn-position isomer resolving power. Nat. Commun. 2020, 11 (1), 375.